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晋小婷 教授

2019年09月17日 08:15  点击:[]



  晋小婷,理学博士,青岛大学特聘教授,硕士生导师;荣获“泰山学者青年专家”和“山西省教育领域‘三晋英才’——青年优秀人才”称号。长期致力于研究环境污染物的健康效应及机理,旨在揭示环境因素在疾病发展恶化中的作用;近年来围绕典型环境污染物(大气细颗粒物和新型有机污染物)与心血管疾病和肿瘤的相关性及毒性机制开展了深入研究,取得一系列创新性成果,研究成果发表于Journal of Hazardous Materials, Environmental Science & Technology, Archives of Toxicology, Science of the Total Environment, Environmental Pollution等期刊。已在国内外学术杂志发表论文36篇,第一或通讯作者SCI收录论文19篇,其中影响因子大于5的论文12篇;代表性论文荣获山西省第十九届优秀论文一等奖和二等奖。主持科研项目5项,其中国家自然科学基金面上项目1项、国家自然科学基金青年项目1项、山东省泰山青年学者项目1项等项目;作为科研骨干参加完成了多项重点基金项目的研究工作。

一、主要研究方向

  主要揭示典型环境污染物(主要包括新型有机污染物和大气细颗粒物)的肿瘤和心血管疾病风险,筛查关键生物标志物,阐明环境因素在疾病发展恶化中的调控作用。

1. 揭示典型环境污染物与肿瘤相关性并阐述其机制;

2. 寻找型环境污染物诱发心血管风险的生物标志物及毒性机理。

二、代表性科研成果(第一及通讯作者)

1. Huilan Su, Ge Guan, Rifat Zubair Ahmed, Liang Lyu, Zhuoyu Li, Xiaoting Jin*. TBBPA stimulated cell migration of endometrial cancer via the contribution of NOX-generated ROS in lieu of energy metabolism. Journal of Hazardous Materials. 2020, 400, 123204. (IF: 9.038)

2. Ze Zhang, Huilan Su, Rifat Zubair Ahmed, Yuxin Zheng, Xiaoting Jin*. Critical biomarkers for myocardial damage by fine particulate matter: Focused on PPARα-regulated energy metabolism. Environmental Pollution. 2020, 264, 114659. (IF: 6.792)

3. Jingxu Zhang, Qunfang Zhou, Ruijun Su, Zhendong Sun, Weifang Zhang, Xiaoting Jin*, Yuxin Zheng. Cardiac dysfunction and metabolic remodeling due to seasonally ambient fine particles exposure. Science of the Total Environment. 2020, 721, 137792. (IF: 6.551)

4. Ruijun Su#, Xiaoting Jin#, Hanqing Li, Leiru Huang, Zhuoyu Li*. The mechanisms of PM2.5 and its main components penetrate into HUVEC cells and effects on cell organelles. Chemosphere. 2020, 241, 125127. (IF: 5.778, 并列第一)

5. Liang Lyu#, Xiaoting Jin#, Zhuoyu Li*, Sha Liu, Yi Li, Ruijun Su, Huilan Su. TBBPA regulates calcium-mediated lysosomal exocytosis and thereby promotes invasion and migration in hepatocellular carcinoma. Ecotoxicology and Environmental Safety. 2020, 192, 110255. (IF: 4.872, 并列第一)

6. Xiaoting Jin, Qianchi Ma, Zhendong Sun, Xuezhi Yang, Qunfang Zhou*, Guangbo Qu, Qian Liu, Chunyang Liao, Zhuoyu Li, Guibin Jiang. Airborne fine particles induce hematological effects through regulating the crosstalk of the kallikrein-kinin, complement and coagulation systems. Environmental Science & Technology. 2019, 53 (5), 2840-51. (IF: 7.864)

7. Xiaoting Jin, Bin Xue, Rifat Zubair Ahmed, Guobin Ding, Zhuoyu Li*. Fine particles cause the abnormality of cardiac ATP levels via PPARɑ-mediated utilization of fatty acid and glucose using in vivo and in vitro models. Environmental Pollution. 2019, 249, 286-94. (IF: 6.792)

8. Xiaoting Jin, Huilan Su, Guobin Ding, Zhendong Sun, Zhuoyu Li*. Exposure to ambient fine particles causes abnormal energy metabolism and ATP decrease in lung tissues. Chemosphere. 2019, 224, 29-38. (IF: 5.778)

9. Ruijun Su#, Xiaoting Jin#, Liang Lyu, Junsheng Tian, Sajid Amin, Zhuoyu Li*. The potential immunotoxicity of fine particulate matter based on SD rat spleen. Environmental Science and Pollution Research. 2019, 26 (23), 23958-66. (IF: 3.056, 并列第一)

10. Xiaoting Jin, Bin Xue, Qunfang Zhou, Ruijun Su, Zhuoyu Li*. Mitochondrial damage-mediated by ROS incurs bronchial epithelial cell apoptosis upon ambient PM2.5 exposure. The Journal of Toxicological Sciences. 2018, 43 (2), 101-11. (IF: 1.737)

11. Ruijun Su#, Xiaoting Jin#, Weifang Zhang, Zhuoyu Li*, Xiaona Liu, Jie Ren. Particulate matter exposure induces the autophagy of macrophages via oxidative stress-mediated PI3K/AKT/mTOR pathway. Chemosphere. 2017, 167, 444-53. (IF: 5.778, 并列第一)

12. Xiaona Liu#, Xiaoting Jin#, Ruijun Su, Zhuoyu Li*. The reproductive toxicology of male SD rats after PM2.5 exposure mediated by the stimulation of endoplasmic reticulum stress. Chemosphere. 2017, 189, 547-55. (IF: 5.778, 并列第一)

13. Xiaoting Jin, Li Song, Xiangyuan Liu, Hangqing Li, Long Cheng, Zhuoyu Li*. Protective effects of vitamins C and E on dichlorodiphenyltrichloroethane-induced genotoxicity and hepatotoxicity in human liver cells. Molecular & Cellular Toxicology. 2017, 13 (2), 155-64. (IF: 1.660)

14. Xiaoting Jin, Meilan Chen, Ruijin Li, Quan An, Li Song, Yi Zhao, Hong Xiao, Long Cheng*, and Zhuoyu Li*. Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure. Archives of Toxicology. 2016, 90 (8), 1929-38. (IF: 5.059)

15. Xiaoting Jin, Ruijun Su, Ruijin Li, Li Song, Meilan Chen, Long Cheng, Zhuoyu Li*. Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells. Chemosphere. 2016, 144, 459-66. (IF: 5.778)

16. Xiaoting Jin, Li Song, Zhuoyu Li*, Ian P. Newton, Meirong Zhao, Weiping Liu. Dichlorodiphenyldichloroethylene exposure reduces r-GCS via the suppressed Nrf2 pathway in HepG2 cells. Environmental Toxicology. 2016, 31(3), 350-9. (IF: 3.118)

17. Xiaoting Jin, Meilan Chen, Li Song, Hanqing Li, Zhuoyu Li*. The evaluation of p,p'-DDT exposure on cell adhesion of hepatocellular carcinoma. Toxicology. 2014, 322, 99-108. (IF: 4.099)

18. Xiaoting Jin, Li Song, Junyu Zhao, Zhuoyu Li*, Meirong Zhao, Weiping Liu. Dichlorodiphenyltrichloroethane exposure induces the growth of hepatocellular carcinomavia Wnt/β-catenin pathway. Toxicology Letters. 2014, 225, 158–66. (IF: 3.569)

19. Xiaoting Jin, Li Song, Xiangyuan Liu, Meilan Chen, Zhuoyu Li*, Long Cheng, Hua Ren. Protective efficacy of Vitamins C and E on p,p'-DDT-induced cytotoxicity via the ROS-mediated mitochondrial pathway and NF-kB/FasL pathway. PloS one. 2014, 9(12), e113257. (IF: 2.740)

三、主持承担科研和人才项目情况

1. 国家自然科学基金面上项目,21976114,大气细颗粒物影响肺部血小板生成的理化因素及机制,2020/01-2023/12,65.00万元,项目负责人。

2. 国家自然科学基金青年项目,21707085,环境PM2.5通过PPARɑ介导的心肌能量代谢重构诱导心力衰竭的毒性机制,2018/01-2020/12,26.00万元,项目负责人。

3. 山西省青年基金项目,201701D221244,TBBPA通过影响巨噬细胞极化介导子宫内膜癌恶化的分子毒理研究,2017/07-2019/12,3.00万元,项目负责人。

4. 中国博士后基金一等资助,2017M610120,环境PM2.5暴露引起大鼠心力衰竭的毒性效应及机制研究,2017/06-2019/12, 8.00万元,项目负责人。

5. 山东省组织部,泰山学者青年专家人才计划,2020.01-2024.12。

联系方式

E-mail:xtjin@qdu.edu.cn;879085335@qq.com



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