赵艳洁，女，1988年4月生，山东聊城人。2017年7月毕业于北京协和医学院，获肿瘤学博士学位。现为青岛大学公共卫生学院副教授，硕士生导师，青岛大学特聘教授第五层次。 主要从事毒理学的科研与教学工作，现为中国毒理学会会员、山东预防医学会卫生毒理学分会委员。主持国家自然科学基金面上项目、国家自然科学基金青年项目、山东省自然科学基金项目、山东省高等学校优秀青年创新团队项目等多项。以第一和通讯作者发表论文17篇，总影响因子达100多分。
一、主要研究方向
1、环境污染物致癌的表观遗传调控
2、生物大分子相分离在环境污染物毒性效应中的作用机制
二、代表性科研成果
(1)Zhao YJ #, Wei LX#, Shao MM, Huang XD, Chang J, Zheng J, Chu JH, Cui QH, Peng LN, Luo YY, Tan WL, Tan W, Lin DX*, Wu C*, BRCA1 Associated Protein Increases Invasiveness of Esophageal Squamous-Cell Carcinoma. Gastroenterology, 2017;153:1304-1319. (IF: 20.773)
(2)Chen X, Chen HG, Zhang PM, Ju Q, Wu ZX, Xu N, Bi Q, Yang SS, Ji J, Yu DK, Zhao YJ*. Coke oven emissions exacerbate allergic asthma by promoting ferroptosis in airway epithelial cells. J Hazard Mater. 2024; 478:135542. (IF: 12.2)
(3)Wu ZX, Zhang H, Chen X, Zhang PM, Fang JC, Yang SS, Chen HG, Ji J, Chen L, Zheng YX, Yu DK, Zhao YJ*. miR-145a-5p/SIK1/cAMP-dependent alteration of synaptic structural plasticity drives cognitive impairment induced by coke oven emissions. Ecotoxicol Environ Saf. 2024; 1:277:116401. (IF:6.2)
(4)Jia MM, Yi BC, Chen X, Xu YZ, Xu XK, Wu ZX, Ji J, Tang JL, Yu DK, Zheng YX, Zhou QH*, Zhao YJ*. Carbon dots induce pathological damage to the intestine via causing intestinal flora dysbiosis and intestinal inflammation. J Nanobiotechnology. 2023;21(1):167. (IF:10.2)
(5)Zhang H, Li XM, Jia MM, Ji J, Wu ZX, Chen X, Yu DK, Zheng YX, Zhao YJ*. Roles of H19/miR-29a-3p/COL1A1 axis in COE-induced lung cancer. Environ Pollut, 2022, 313: 120194. (IF:9.988)
(6)Zhao YJ, Li XM, Zhang H, Yan MZ, Jia MM, Zhou QH*. A Transcriptome Sequencing Study on Genome-Wide Gene Expression Differences of Lung Cancer Cells Modulated by Fucoidan. Front Bioeng Biotechnol, 2022; 10:844924. (IF: 5.89)
(7)Zhao ZY, Ju Q, Ji J, Li YT, Zhao YJ*. N6-Methyladenosine Methylation Regulator RBM15 is a Potential Prognostic Biomarker and Promotes Cell Proliferation in Pancreatic Adenocarcinoma. Front Mol Biosci, 2022; 9:842833. (IF: 5.246)
(8)Chen X, Jia MM, Ji J, Zhao ZY, Zhao YJ*. Exosome-Derived Non-Coding RNAs in the Tumor Microenvironment of Colorectal Cancer: Possible Functions, Mechanisms and Clinical Applications. Front Oncol. 2022; 12:887532. (IF: 4.599)
(9)Zhao YJ#, Zhang H#, Ju Q, Li XM, Zheng YX*. Comprehensive Analysis of Survival-Related lncRNAs, miRNAs, and mRNAs Forming a Competing Endogenous RNA Network in Gastric Cancer. Front Genet, 2021; 12:610501. (IF: 4.599)
(10)Li XM, Zhang H, Xu L, Jin Y, Luo J, Li CH, Zhao KM, Zheng YX, Yu DK, Zhao YJ*. miR-15a-3p Protects Against Isoniazid-Induced Liver Injury via Suppressing N-Acetyltransferase 2 Expression. Front Mol Biosci, 2021; 8:752072. (IF: 5.246)
(11)Ju Q#, Li XM#, Zhang H, Yan SX, Li Y, Zhao YJ*. NFE2L2 Is a Potential Prognostic Biomarker and Is Correlated with Immune Infiltration in Brain Lower Grade Glioma: A Pan-Cancer Analysis. Oxid Med Cell Longev, 2020:3580719. (IF: 6.543)
(12)Ju Q, Li XM, Zhang H, Zhao YJ*. BRCA1-Associated Protein Is a Potential Prognostic Biomarker and Is Correlated with Immune Infiltration in Liver Hepatocellular Carcinoma: A Pan-Cancer Analysis. Front Mol Biosci, 2020;7:573619. (IF: 5.246)
(13)Ju Q#*, Zhao YJ#, Ma S, Li XM, Zhang H, Zhang SQ, Yang YM, Yan SX. Genome-wide analysis of prognostic-related lncRNAs, miRNAs and mRNAs forming a competing endogenous RNA network in lung squamous cell carcinoma. J Cancer Res Clin Oncol, 2020;146(7):1711-1723. (IF: 4.553)
(14)Wang XB#, Zhao YJ#, Luo J, Xu L, Li XM, Jin Y, Li CH, Feng MY, Wang Y, Chen J, Hou YF, Zhao QW, Zhao J, Ning BT, Zheng YX, Yu DK*. MicroRNA hsa-miR-1301-3p Regulates Human ADH6, ALDH5A1 and ALDH8A1 in the Ethanol-Acetaldehyde-Acetate Metabolic Pathway. Mol Pharmacol, 2020; 98(2): 120-129. (IF: 4.436)
(15)Ju Q#, Zhao YJ#, Dong Y, Cheng C, Zhang SQ, Yang YM, Li P, Ge DM, Sun B*. Identification of a miRNA‑mRNA network associated with lymph node metastasis in colorectal cancer. Oncol Lett, 2019;18(2):1179-1188. (IF: 2.311)
(16)Ju Q#, Zhao YJ#, Liu YJ, Zhou GH, Li F, Xie PL, Li YH, Li GC*. Monoclonal antibody preparation of Golgi phosphoprotein 2 and preliminary application in the early diagnosis of hepatocellular carcinoma, Molecular Medicine Reports, 2013;8(2):517–522.
(17)Zhao YJ, Ju Q, Li GC*. Tumor markers for hepatocellular carcinoma. Molecular and Clinical Oncology, 2013;1(4):593–598.
三、主要科研项目
1、lncRNA SFTA1P调控乙酰辅酶A代谢重编程在焦炉逸散物致肺癌中的机制研究，国家自然科学基金面上项目，54万，2022-2025，主持
2、整合多组学数据解析增强子变异在柴油机尾气致癌中的分子机制，山东省高等学校优秀青年创新团队. 2024-2026，主持
3、GSR调控结直肠癌肝脏转移前微环境形成的作用及机制研究，国家自然科学基金青年项目，30万，2023-2025，骨干
4、BRCA1相关蛋白BRAP通过调控微环境促进食管癌转移的机制研究，国家自然科学基金青年科学基金项目，22万，2019-2021，主持
5、BRCA1相关蛋⽩BRAP促进⾷管癌转移的机制研究，山东省自然科学基金，5万，2018-2020，主持
四、联系方式：
zhaoyj@qdu.edu.cn
