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刘洁 教授

2021年09月09日 17:24  点击:[]

  

  刘洁,青岛大学公共卫生学院微生物检验与生物安全系教授。2021年8月入职青大公卫学院,之前为美国弗吉尼亚大学副教授。自2009年以来一直从事传染病的分子诊断、多病原监测方面的研究,参与了多项盖茨基金会、世界卫生组织、美国疾控中心等资助的多国、多中心的传染病病原监测项目。建立了基于症状的、多病原检测体系,并应用于多种传染病的病因、流行病学研究,包括急性发热、脑炎、呼吸道疾病等等,广受关注的是腹泻疾病方面的工作,相继有5篇论文发表在Lancet及其子刊上,2篇在Science及其子刊上;其中4篇为或曾经为高引用论文。目前在此方向发表SCI论文60余篇,为20余家国外学术期刊审稿。


一、主要研究方向

传染病的病因学研究,传染病的动物溯源,细菌抗药性研究,分子诊断技术研发

二、目前执行的项目

  国家重点研发计划项目“多学科视角新冠病毒溯源研究”,子课题“候鸟携带病原体的分子监测”,负责人

三、代表性科研成果(#共同第一作者)

1. Marks F, Liu J, Soura AB, Gasmelseed N, Operario D, Grundy B, Wieser J, Gratz J, Meyer CG, Im J, Lim JK, von Kalckreuth V, Cruz Espinoza LM, Konings F, Jeon HJ, Rakotozandrindrainy R, Zhang J, Panzner U, Houpt E. Pathogens causing acute febrile illness among children and adolescents in Burkina Faso, Madagascar and Sudan. Clin Infect Dis. 2021 Apr 2:ciab289. doi: 10.1093/cid/ciab289.

2. Liu J, Pholwat S, Zhang J, Taniuchi M, Haque R, Alam M, Ochieng JB, Jones JA, Platts-Mills JA, Tennant SM, Houpt E. Evaluation of Molecular Serotyping Assays for Shigella flexneri Directly on Stool Samples. J Clin Microbiol. 2020 Nov 25;JCM.02455-20.

3. Rogawski McQuade ET, Liu J, Kang G, Kosek MN, Lima AAM, Bessong PO, Samie A, Haque R, Mduma ER, Shrestha S, Leite JP, Bodhidatta L, Iqbal N, Page N, Kiwelu I, Bhutta Z, Ahmed T, Houpt ER, Platts-Mills JA. Protection from natural immunity against enteric infections and etiology-specific diarrhea in a longitudinal birth cohort. J Infect Dis. 2020 Nov 9;222(11):1858-1868.

4. McMurry TL, McQuade ETR, Liu J, Kang G, Kosek MN, Lima AAM, Bessong PO, Samie A, Haque R, Mduma ER, Leite JP, Bodhidatta L, Iqbal N, Page N, Kiwelu I, Bhutta ZA, Ahmed T, Houpt ER, Platts-Mills JA. Duration of post-diarrheal enteric pathogen carriage in young children in low-resource settings. Clin Infect Dis. 2021 June 1; 72(11):e806-e814.

5. Kwambana-Adams BA#, Liu J#, Okoi C, Mwenda JM, Mohammed NI, Tsolenyanu E, Renner LA, Ansong D, Tagbo BN, Bashir MF, Hama MK, Sonko MA, Gratz J, Worwui A, Ndow P, Cohen AL, Serhan F, Mihigo R, Antonio M, Houpt E. Etiology of pediatric meningitis in West Africa using molecular methods in the era of conjugate vaccines against pneumococcus, meningococcus, and Haemophilus influenzae type b. Am J Trop Med Hyg. 2020 Aug;103(2):696-703.

6. Burnett E#, Kabir F#, Van Trang N, Rayamajhi A, Satter SM, Liu J#, Yousafzai MT, Anh DD, Basnet AT, Flora MS, Houpt E, Qazi SH, Canh TM, Rayamajhi AK, Saha BK, Saddal NS, Muneer S, Hung PH, Islam T, Ali SA, Tate JE, Yen C, Parashar UD; Asian Intussusception Surveillance Network. Infectious etiologies of intussusception among children <2 years old in 4 Asian countries. J Infect Dis. 2020 Apr 7, 221(9): 1499-1505.

7. Pholwat S, Liu J, Taniuchi M, Chinli R, Pongpan T, Thaipisutikul I, Ratanakorn P, Platts-Mills JA, Fleece M, Stroup S, Gratz J, Mduma E, Mujaga B, Walongo T, Nshama R, Kimathi C, Foongladda S, Houpt E. Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens. PLOS ONE. 2019 May 10;14(5):e0216747.

8. Moore CC, Jacob ST, Banura P, Zhang J, Stroup SE, Boulware DR, Scheld WM, Houpt ER#, Liu J#. Etiology of sepsis in Uganda using a quantitative PCR-based TaqMan Array Card. Clin Infect Dis. 2019 Jan 7;68(2):266-272.

9. Platts-Mills JA#, Liu J#, Rogawski ET, Kabir F, Lertsethtakarn P, Siguas M, Khan SS, Praharaj I, Murei A, Nshama R, Mujaga B, Havt A, Maciel IA, McMurry TL, Operario DJ, Taniuchi M, Gratz J, Stroup SE, Roberts JH, Kalam A, Aziz F, Qureshi S, Islam MO, Sakpaisal P, Silapong S, Yori PP, Rajendiran R, Benny B, McGrath M, McCormick BJJ, Seidman JC, Lang D, Gottlieb M, Guerrant RL, Lima AAM, Leite JP, Samie A, Bessong PO, Page N, Bodhidatta L, Mason C, Shrestha S, Kiwelu I, Mduma ER, Iqbal NT, Bhutta ZA, Ahmed T, Haque R, Kang G, Kosek MN, Houpt ER, and the MAL-ED Network Investigators. Use of quantitative molecular diagnostic methods to assess the aetiology, burden and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study. Lancet Global Health, 2018 Dec;6(12):e1309-e1318.

10. Rogawski ET#, Liu J#, Platts-Mills JA, Kabir F, Lertsethtakarn P, Siguas M, Khan SS, Praharaj I, Murei A, Nshama R, Mujaga B, Havt A, Maciel IA, Operario DJ, Taniuchi M, Gratz J, Stroup SE, Roberts JH, Kalam A, Aziz F, Qureshi S, Islam MO, Sakpaisal P, Silapong S, Yori PP, Rajendiran R, Benny B, McGrath M, Seidman JC, Lang D, Gottlieb M, Guerrant RL, Lima AAM, Leite JP, Samie A, Bessong PO, Page N, Bodhidatta L, Mason C, Shrestha S, Kiwelu I, Mduma ER, Iqbal NT, Bhutta ZA, Ahmed T, Haque R, Kang G, Kosek MN, Houpt ER, and the MAL-ED Network Investigators. Use of quantitative molecular diagnostic methods to investigate the effect of enteropathogen infections on linear growth in children in low-resource settings: longitudinal analysis of results from the MAL-ED cohort study. Lancet Global Health, 2018 Dec;6(12):e1319-e1328.

11. Liu J, Almeida M, Kabir F, Shakoor S, Qureshi S, Zaidi A, Li S, Tamboura B, Sow SO, Mandomando I, Alonso PL, Ramamurthy T, Sur D, Kotloff K, Nataro J, Levine MM, Stine OC, Houpt E. Direct Detection of Shigella in Stool Specimens by Use of a Metagenomic Approach. J Clin Microbiol. 2018 Jan 24;56(2). pii: e01374-17.

12. Pholwat S, Liu J, Stroup S, Jacob S, Banura P, Moore C, Huang F, Laufer M, Houpt E, Guler J. The malaria TaqMan Array Card: 87 assays for Plasmodium falciparum drug resistance, speciation, and genotyping in a single reaction. Antimicrob. Agents Chemother, e00110-17, 2017.

13. Liu J#, Platts-Mills JA#, Juma J, Kabir F, Nkeze J, Okoi C, Operario DJ, Uddin J, Ahmed S, Alonso PL, Antonio M, Becker SM, Blackwelder WC, Breiman RF, Faruque ASG, Fields B, Gratz J, Haque R, Hossain A, Hossain MJ, Jarju S, Qamar F, Iqbal NT, Kwambana B, Mandomando I, McMurry TL, Ochieng C, Ochieng JB, Ochieng M, Onyango C, Panchalingam S, Kalam A, Aziz F, Qureshi S, Ramamurthy T, Roberts JH, Saha D, Sow SO, Stroup SE, Sur D, Tamboura B, Taniuchi M, Tennant SM, Toema D, Wu Y, Zaidi A, Nataro JP, Kotloff KL, Levine MM, Houpt ER. Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study. Lancet. 2016 Sep: 388:1291-301.

14. Grassly NC, Praharaj I, Babji S, Kaliappan SP, Giri S, Venugopal S, Parker EPK, Abraham A, Muliyil J, Doss S, Raman U, Liu J, Peter JV, Paranjape M, Jeyapaul S, Balakumar S, Ravikumar J, Srinivasan R, Bahl S, Iturriza-Gómara M, Uhlig HH, Houpt ER, John J, Kang G. The effect of azithromycin on the immunogenicity of oral poliovirus vaccine: a double-blind randomised placebo-controlled trial in seronegative Indian infants. Lancet Infectious Diseases, 2016, 16(8): 905-914.

15. Liu J, Ochieng C, Wiersma S, Ströher U, Towner JS, Whitmer S, Nichol ST, Moore CC, Kersh GJ, Kato C, Sexton C, Petersen J, Massung R, Hercik C, Crump JA, Kibiki G, Maro A, Mujaga B, Gratz J, Jacob ST, Banura P, Scheld WM, Juma B, Onyango CO, Montgomery JM, Houpt E, Fields B. Development of a TaqMan Array Card for Acute-Febrile-Illness Outbreak Investigation and Surveillance of Emerging Pathogens, including Ebola Virus. J. Clin. Microbiol. 2016 Jan;54(1):49-58.

16. Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I, Manary MJ, Liu TC, Stappenbeck TS, Maleta KM, Ashorn P, Dewey KG, Houpt ER, Hsieh CS, Gordon JI. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci. Transl. Med. 2015 Feb 25; 7(276): 276ra24.

17. Pholwat S, Liu J, Stroup S, Gratz J, Banu S, Rahman SMM, Ferdous S, Foongladda S, Boonlert D, Ogarkov O, Zhdanova S, Kibiki G, Heysell S, Houpt ER. Integrated Microfluidic Card with TaqMan Probes and High Resolution Melt Analysis to Detect Tuberculosis Drug Resistance Mutations across 10 Genes. mBio 2015 Feb 24; 6(2): e02273.

18. Liu J, Kabir F, Manneh J, Lertsethtakarn P, Begum S, Gratz J, Becker SM, Operario DJ, Taniuchi M, Janaki L, Platts-Mills JA, Haverstick DM, Kabir M, Sobuz SU, Nakjarung K, Sakpaisal P, Silapong S, Bodhidatta L, Qureshi S, Kalam A, Saidi Q, Swai N, Mujaga B, Maro A, Kwambana B, Dione M, Antonio M, Kibiki G, Mason CJ, Haque R, Iqbal N, Zaidi AK, Houpt ER. Development and assessment of molecular diagnostic tests for 15 enteropathogens causing childhood diarrhoea: a multicenter study. Lancet Infect. Dis. 2014 Aug; 14(8): 716-24.

19. Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J, Kau AL, Rich SS, Concannon P, Mychaleckyj JC, Liu J, Houpt E, Li JV, Holmes E, Nicholson J, Knights D, Ursell LK, Knight R, Gordon JI. Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor. Science, 339(6119): 548-554, 2013.

20. Liu J, Gratz J, Amour C, Kibiki G, Becker S, Janaki L, Verweij JJ, Taniuchi M, Sobuz SU, Haque R, Haverstick D, Houpt ER. A laboratory-developed TaqMan array card for simultaneous detection of 19 enteropathogens. J Clinical Microbiology, 51(2): 472-480, 2013.



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