刘洁，2021年11月入职青岛大学，公共卫生学院微生物检验与生物安全系教授，博士生导师，兼任青岛市疾控中心外聘专家，美国弗吉尼亚大学全球健康中心客座教授。自2009年以来一直从事传染病的分子诊断研究，建立了基于症状的、多病原检测体系，并应用于多种传染病的病因、流行病学研究，包括急性发热、脑炎、腹泻、肺炎等，以及疫苗、抗生素、营养素等干预手段的效力评价；主持、参与了多项比尔盖茨基金会、世界卫生组织、美国疾控中心等资助的多国、多中心的传染病病原监测项目，其中有关腹泻病因的研究结果被华盛顿州西雅图健康指标和评估研究所作为依据用于全球疾病负担的评估。目前发表SCI论文90余篇，累计他引超过3500次，H-Index 27。
一、主要研究方向
传染病的病因学和流行病学研究，媒介生物携带病原的监测，细菌抗药性研究，分子诊断技术研发
二、目前在研项目
国家重点研发计划项目“多学科视角病毒溯源研究”，子课题“候鸟携带病原体的分子监测”
比尔盖茨基金会“Core support for diarrheal disease studies”项目分包合同
三、代表性科研成果（#共同第一作者，*通讯作者）
1. Li Y, Wang Y, Liu J*. Genomic insights into the interspecific diversity and evolution of Mobiluncus, a pathogen associated with bacterial vaginosis. Front. Microbiol. 2022, 13:939406.
2. Van Aartsen D, Justine M, Mduma E, Mpagama SG, Alshaer MH, Peloquin CA, Mujaga B, Maro A, Gratz J, Kosek M, Liu J, McQuade ETR, Houpt ER, Thomas TA, Heysell SK. Enteropathogen spectrum and effect on antimycobacterial pharmacokinetics among children with tuberculosis in rural Tanzania: a prospective cohort study. Lancet Microbe. 2022, 3(6): e408-16.
3. Marks F, Liu J, Soura AB, Gasmelseed N, Operario D, Grundy B, Wieser J, Gratz J, Meyer CG, Im J, Lim JK, von Kalckreuth V, Cruz Espinoza LM, Konings F, Jeon HJ, Rakotozandrindrainy R, Zhang J, Panzner U, Houpt E. Pathogens causing acute febrile illness among children and adolescents in Burkina Faso, Madagascar and Sudan. Clin Infect Dis. 2021, 73(8):1338-45.
4. Liu J*, Pholwat S, Zhang J, Taniuchi M, Haque R, Alam M, Ochieng JB, Jones JA, Platts-Mills JA, Tennant SM, Houpt E. Evaluation of Molecular Serotyping Assays for Shigella flexneri Directly on Stool Samples. J Clin Microbiol. 2020 Nov 25; 02455-20.
5. Kwambana-Adams BA#, Liu J#, Okoi C, Mwenda JM, Mohammed NI, Tsolenyanu E, Renner LA, Ansong D, Tagbo BN, Bashir MF, Hama MK, Sonko MA, Gratz J, Worwui A, Ndow P, Cohen AL, Serhan F, Mihigo R, Antonio M, Houpt E. Etiology of pediatric meningitis in West Africa using molecular methods in the era of conjugate vaccines against pneumococcus, meningococcus, and Haemophilus influenzae type b. Am J Trop Med Hyg. 2020 Aug;103(2):696-703.
6. Moore CC, Jacob ST, Banura P, Zhang J, Stroup SE, Boulware DR, Scheld WM, Houpt ER#, Liu J#. Etiology of sepsis in Uganda using a quantitative PCR-based TaqMan Array Card. Clin Infect Dis. 2019 Jan 7;68(2):266-272.
7. Platts-Mills JA#, Liu J#, Rogawski ET, Kabir F, Lertsethtakarn P, Siguas M, Khan SS, Praharaj I, Murei A, Nshama R, Mujaga B, Havt A, Maciel IA, McMurry TL, Operario DJ, Taniuchi M, Gratz J, Stroup SE, Roberts JH, Kalam A, Aziz F, Qureshi S, Islam MO, Sakpaisal P, Silapong S, Yori PP, Rajendiran R, Benny B, McGrath M, McCormick BJJ, Seidman JC, Lang D, Gottlieb M, Guerrant RL, Lima AAM, Leite JP, Samie A, Bessong PO, Page N, Bodhidatta L, Mason C, Shrestha S, Kiwelu I, Mduma ER, Iqbal NT, Bhutta ZA, Ahmed T, Haque R, Kang G, Kosek MN, Houpt ER, and the MAL-ED Network Investigators. Use of quantitative molecular diagnostic methods to assess the aetiology, burden and clinical characteristics of diarrhoea in children in low-resource settings: a reanalysis of the MAL-ED cohort study. Lancet Global Health, 2018 Dec;6(12):e1309-e1318.
8. Rogawski ET#, Liu J#, Platts-Mills JA, Kabir F, Lertsethtakarn P, Siguas M, Khan SS, Praharaj I, Murei A, Nshama R, Mujaga B, Havt A, Maciel IA, Operario DJ, Taniuchi M, Gratz J, Stroup SE, Roberts JH, Kalam A, Aziz F, Qureshi S, Islam MO, Sakpaisal P, Silapong S, Yori PP, Rajendiran R, Benny B, McGrath M, Seidman JC, Lang D, Gottlieb M, Guerrant RL, Lima AAM, Leite JP, Samie A, Bessong PO, Page N, Bodhidatta L, Mason C, Shrestha S, Kiwelu I, Mduma ER, Iqbal NT, Bhutta ZA, Ahmed T, Haque R, Kang G, Kosek MN, Houpt ER, and the MAL-ED Network Investigators. Use of quantitative molecular diagnostic methods to investigate the effect of enteropathogen infections on linear growth in children in low-resource settings: longitudinal analysis of results from the MAL-ED cohort study. Lancet Global Health, 2018 Dec;6(12):e1319-e1328.
9. Liu J, Almeida M, Kabir F, Shakoor S, Qureshi S, Zaidi A, Li S, Tamboura B, Sow SO, Mandomando I, Alonso PL, Ramamurthy T, Sur D, Kotloff K, Nataro J, Levine MM, Stine OC, Houpt E. Direct Detection of Shigella in Stool Specimens by Use of a Metagenomic Approach. J Clin Microbiol. 2018 Jan 24;56(2).
10. Liu J#, Platts-Mills JA#, Juma J, Kabir F, Nkeze J, Okoi C, Operario DJ, Uddin J, Ahmed S, Alonso PL, Antonio M, Becker SM, Blackwelder WC, Breiman RF, Faruque ASG, Fields B, Gratz J, Haque R, Hossain A, Hossain MJ, Jarju S, Qamar F, Iqbal NT, Kwambana B, Mandomando I, McMurry TL, Ochieng C, Ochieng JB, Ochieng M, Onyango C, Panchalingam S, Kalam A, Aziz F, Qureshi S, Ramamurthy T, Roberts JH, Saha D, Sow SO, Stroup SE, Sur D, Tamboura B, Taniuchi M, Tennant SM, Toema D, Wu Y, Zaidi A, Nataro JP, Kotloff KL, Levine MM, Houpt ER. Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study. Lancet. 2016 Sep: 388:1291-301.
11. Grassly NC, Praharaj I, Babji S, Kaliappan SP, Giri S, Venugopal S, Parker EPK, Abraham A, Muliyil J, Doss S, Raman U, Liu J, Peter JV, Paranjape M, Jeyapaul S, Balakumar S, Ravikumar J, Srinivasan R, Bahl S, Iturriza-Gómara M, Uhlig HH, Houpt ER, John J, Kang G. The effect of azithromycin on the immunogenicity of oral poliovirus vaccine: a double-blind randomised placebo-controlled trial in seronegative Indian infants. Lancet Infectious Diseases, 2016, 16(8): 905-914.
12. Liu J, Ochieng C, Wiersma S, Ströher U, Towner JS, Whitmer S, Nichol ST, Moore CC, Kersh GJ, Kato C, Sexton C, Petersen J, Massung R, Hercik C, Crump JA, Kibiki G, Maro A, Mujaga B, Gratz J, Jacob ST, Banura P, Scheld WM, Juma B, Onyango CO, Montgomery JM, Houpt E, Fields B. Development of a TaqMan Array Card for Acute-Febrile-Illness Outbreak Investigation and Surveillance of Emerging Pathogens, including Ebola Virus. J. Clin. Microbiol. 2016 Jan;54(1):49-58.
13. Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I, Manary MJ, Liu TC, Stappenbeck TS, Maleta KM, Ashorn P, Dewey KG, Houpt ER, Hsieh CS, Gordon JI. Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy. Sci. Transl. Med. 2015 Feb 25; 7(276): 276ra24.
14. Liu J, Kabir F, Manneh J, Lertsethtakarn P, Begum S, Gratz J, Becker SM, Operario DJ, Taniuchi M, Janaki L, Platts-Mills JA, Haverstick DM, Kabir M, Sobuz SU, Nakjarung K, Sakpaisal P, Silapong S, Bodhidatta L, Qureshi S, Kalam A, Saidi Q, Swai N, Mujaga B, Maro A, Kwambana B, Dione M, Antonio M, Kibiki G, Mason CJ, Haque R, Iqbal N, Zaidi AK, Houpt ER. Development and assessment of molecular diagnostic tests for 15 enteropathogens causing childhood diarrhoea: a multicenter study. Lancet Infect. Dis. 2014 Aug; 14(8): 716-24.
15. Smith MI, Yatsunenko T, Manary MJ, Trehan I, Mkakosya R, Cheng J, Kau AL, Rich SS, Concannon P, Mychaleckyj JC, Liu J, Houpt E, Li JV, Holmes E, Nicholson J, Knights D, Ursell LK, Knight R, Gordon JI. Gut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor. Science, 339(6119): 548-554, 2013.
16. Liu J, Gratz J, Amour C, Kibiki G, Becker S, Janaki L, Verweij JJ, Taniuchi M, Sobuz SU, Haque R, Haverstick D, Houpt ER. A laboratory-developed TaqMan array card for simultaneous detection of 19 enteropathogens. J Clinical Microbiology, 51(2): 472-480, 2013.
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